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KMID : 0861420100140010067
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Korean Journal of Nuclear Medicine Technology
2010 Volume.14 No. 1 p.67 ~ p.72
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The Influence Evaluation of 201Tl Myocardial Perfusion SPECT Image According to the Elapsed Time Difference after the Whole Body Bone Scan
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Kim Dong-Seok
Yoo Hee-Jae
Ryu Jae-Kwang
Yoo Jae-Sook
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Abstract
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Purpose: In Asan Medical Center we perform myocardial perfusion SPECT to evaluate cardiac event risk level for non-cardiac surgery patients. In case of patients with cancer, we check tumor metastasis using whole body bone scan and whole body PET scan and then perform myocardial perfusion SPECT to reduce unnecessary exam. In case of short term in patients, we perform 201Tl myocardial perfusion SPECT after whole body bone scan a minimum 16 hours in order to reduce hospitalization period but it is still the actual condition in which the evaluation about the affect of the crosstalk contamination due to the each other dissimilar isotope administration doesn’t properly realize. So in our experiments, we try to evaluate crosstalk contamination influence on 201Tl myocardial perfusion SPECT using anthropomorphic torso phantom and patient’s data.
Materials and Methods: From 2009 August to September, we analyzed 87 patients with 201Tl myocardial perfusion SPECT. According to 201Tl myocardial perfusion SPECT yesterday whole body bone scan possibility of carrying out, a patient was classified. The image data are obtained by using the dual energy window in 201Tl myocardial perfusion SPECT. We analyzed 201Tl and 99mTc counts ratio in each patients groups obtained image data. We utilized anthropomorphic torso phantom in our experiment and administrated 201Tl 14.8 MBq (0.4 mCi) at myocardium and 99mTc 44.4 MBq (1.2 mCi) at extracardiac region. We obtained image by 201Tl myocardial perfusion SPECT without gate method application and analyzed spatial resolution using Xeleris ver 2.0551.
Results: In case of 201Tl window and the counts rate comparison result yesterday whole body bone scan of being counted in 99mTc window, the difference in which a rate to 24 hours exponential-functionally notes in 1:0.114 with Ventri (GE Healthcare, Wisconsin, USA), 1:0.249 after the bone tracer injection in 12 hours in 1:0.411 with 1:0.79 with Infinia (GE healthcare, Wisconsin, USA) according to a reduction a time-out was shown (Ventri p=0.001, Infinia p=0.001). Moreover, the rate of the case in which it doesn’t perform the whole body bone scan showed up as the average 1:0.067±0.6 of Ventri, and 1:0.063±0.7 of Infinia. According to the phantom after experiment spatial resolution measurement result, and an addition or no and time-out of 99mTc administrated, it doesn’t note any change of FWHM (p=0.134).
Conclusion: Through the experiments using anthropomorphic torso phantom and patients data, we found that 201Tl myocardium perfusion SPECT image later carried out after the bone tracer injection with 16 hours this confirmed that it doesn’t receive notable influence in spatial resolution by 99mTc. But this investigation is only aimed to image quality, so it needs more investigation in patient’s radiation dose and exam accuracy and precision. The exact guideline presentation about the exam interval should be made of the validation test which is exact and in which it is standardized about the affect of the crosstalk contamination according to the isotope use in which it is different later on.
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KEYWORD
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Crosstalk contamination, Myocardial perfusion SPECT, 201Tl
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